Press Release
PhaseBio Highlights Real-World Healthcare Cost and Bleeding Cost Data Featured at the International Society for Pharmacoeconomic and Outcomes Research (ISPOR) Virtual 2021 Conference
Study leveraging the IBM® MarketScan® claims database examined healthcare resource utilization including total healthcare costs and bleeding costs in patients initiating P2Y12 inhibitors, FXa inhibitors or dabigatran
Analyses revealed that patients receiving P2Y12 inhibitors incurred total costs and bleeding-related costs similar to or greater than patients prescribed FXa inhibitors or dabigatran
The poster presentation summarized an analysis of the IBM® MarketScan® Commercial and Medicare Supplemental claims databases and focused on patients newly initiating a P2Y12 inhibitor, factor Xa inhibitor or dabigatran between 2014 and 2018. All patients were required to present ≥1 year of continuous insurance coverage prior to initiating their therapy, and outcomes were measured while patients remained on therapy. Healthcare resource utilization measures focused on total healthcare costs, which were paid amounts from all medical and pharmacy claims, and bleed-related healthcare costs, which were paid amounts from all emergency room (ER) and inpatient (IP) hospital claims that included a diagnosis code for a bleed. Bleeding events included internal bleeds (gastrointestinal, intracranial, and other internal bleeding), external bleeds (trauma-related bleeds/amputations), and bleeding events related to medical procedures.
Results of the analyses demonstrated that, in the year prior to initiating therapy, total healthcare costs were higher among P2Y12 inhibitor patients compared to factor Xa and dabigatran patients. While on therapy, P2Y12 inhibitor patients in the commercial insurance group incurred similar total healthcare costs to factor Xa and dabigatran patients, while Medicare patients on P2Y12 inhibitor therapy incurred higher total healthcare costs than factor Xa and dabigatran patients.
The examination of costs associated with the management of bleeding events in the year prior to initiating therapy revealed that P2Y12 inhibitor patients incurred greater costs than both factor Xa patients and dabigatran patients. Costs to manage bleeding events while patients were taking their antithrombotic medication were similar across classes for both commercially-insured and Medicare patients.
These healthcare cost analyses among patients on antithrombotic medications build on separate analyses from a larger overall study that were recently presented at The
About Bentracimab (PB2452)
Bentracimab is a novel, recombinant, human monoclonal antibody antigen-binding fragment designed to reverse the antiplatelet activity of ticagrelor in major bleeding and urgent surgery situations. In a Phase 1 clinical trial, bentracimab demonstrated the potential to bring life-saving therapeutic benefit through immediate and sustained reversal of ticagrelor’s antiplatelet activity, mitigating concerns regarding bleeding risks associated with the use of this antiplatelet drug. The Phase 1 clinical trial of bentracimab in healthy volunteers was published in the
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